New biological pathway and principal driver of IBD discovered

“Researchers at the Francis Crick Institute, working with UCL and Imperial College London, have discovered a new biological pathway that is a principal driver of inflammatory bowel disease (IBD) and related conditions, and which can be targeted using existing drugs.

About 5% of the world’s population, and one in ten people in the UK, are currently affected by an autoimmune disease, such as IBD, the umbrella term for Crohn’s disease and ulcerative colitis. These diseases are also becoming more common, with over half a million people living with IBD in the UK as of 2022, nearly double the 300,000 previously estimated.

Despite increasing prevalence, current treatments do not work in every patient and attempts to develop new drugs often fail due to our incomplete understanding of what causes IBD.”

You can learn more about this groundbreaking research coming out of the Francis Crick Institute below:

Major cause of inflammatory bowel disease discovered | Crick

You can also read the Nature article here.

A disease-associated gene desert directs macrophage inflammation through ETS2 | Nature